Search results for "ammonium chloride 1"

showing 3 items of 3 documents

Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier

2015

Gene therapy, i.e. the delivery and expression of therapeutic genes, holds great promise for congenital and acquired respiratory diseases. Non-viral vectors are less toxic and immunogenic than viral vectors, although they are characterized by lower efficiency. However, they have to overcome many barriers, including inflammatory and immune mediators and cells. The respiratory and airway epithelial cells, the main target of these vectors, are coated with a layer of mucus, which hampers the effective reaching of gene therapy vectors carrying either plasmid DNA or small interfering RNA. This barrier is thicker in many lung diseases, such as cystic fibrosis. This review summarizes the most impor…

Pulmonary and Respiratory MedicineCystic FibrosisGenetic enhancementContext (language use)Gene deliveryVectors in gene therapyPolyethylene GlycolsViral vectorPolyethyleinimine Poly-L-lysine Ethylene glycol Chitosan PAMAM G0 dendrimer N-(1-(23-Dioleyloxy)propyl)-NNNtrimethylammonium chloride 12-Dioleoylphosphatidylethanolamine N-acetylcystein 12-Dioctadecanoyl-sn-glycero-3-phosphoethanolaminemedicineHumansTechnology PharmaceuticalPharmacology (medical)RNA Small InterferingLungExpectorantsInflammationLungbusiness.industryBiochemistry (medical)Gene Transfer TechniquesGenetic TherapyMucusMucusmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoImmunologyNanoparticlesInflammation MediatorsbusinessPlasmidsRespiratory tract
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CCDC 1411525: Experimental Crystal Structure Determination

2015

Related Article: Hennie Valkenier, Christopher M. Dias, Kathryn L. Porter Goff, Ondřej Jurček, Rakesh Puttreddy, Kari Rissanen, Anthony P. Davis|2015|Chem.Commun.|51|14235|doi:10.1039/C5CC05737J

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersTetramethylammonium chloride 11'1''-((246-triethylbenzene-135-triyl)tris(methylene))tris(3-(35-bis(trifluoromethyl)phenyl)(thiourea)) monohydrateExperimental 3D Coordinates
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CCDC 1408382: Experimental Crystal Structure Determination

2015

Related Article: Toni Mäkelä, Elina Kalenius, and Kari Rissanen|2015|Inorg.Chem.|54|9154|doi:10.1021/acs.inorgchem.5b01577

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersammonium chloride 11'-(23568911121415-decahydro-147101316-benzohexaoxacyclooctadecine-1819-diyl)bis(3-(4-nitrophenyl)urea)Experimental 3D Coordinates
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